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. 2022 Sep 5;11(17):2765. doi: 10.3390/cells11172765

Figure 2.

Figure 2

Differentiation of the purified hiPSC-derived NPCs. After differentiation in the neuronal differentiation medium for 2 weeks, many NPCs differentiated into mature neurons expressing MAP2 (A) and NFL (B). These differentiated neurons were able to generate action potentials during patch clamp recording (C). After differentiation in the astrocyte differentiation medium for 1 month, many NPCs differentiated into immature GFAP+ astrocytes with stellate morphology and long processes (D). After differentiation for 3 months, most astrocytes became more mature with increased size in cytoplasm and fewer processes (E). Scale bars: 100 μm.