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. 2022 Sep 5;11(17):2765. doi: 10.3390/cells11172765

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Spared gray matter after transplantation of hiPSC-NPC. Spared gray matter (GM) in the injured side was quantified using MAP2 immunohistochemistry at 2 months after transplantation (A). The spared GM areas were significantly greater in rostral 0.4, 0.8, and 1.2, or caudal 1.6 mm from injury epicenter, respectively, in rats receiving NPC grafts compared to groups receiving human fibroblasts or culture medium (B). The total spared GM volume in the injury side was also significantly greater in NPC grafting group compared to other two groups (C). Scale bar: A, 500 μm. Data in (B,C) represent the man ± SD (n = 5). * in (B,C), p < 0.05; ** in (B), p < 0.01.