Figure 1.
Some of the genetic pathways and mechanisms affected by phytocannabinoids: THC and CBCA (a) and CBD (b) that are associated with ovarian cancer stem cell state. Receptors are illustrated in cases where receptor involvement in activity was suggested. ABC, ATP-binding cassette transporter; ALDH, aldehyde dehydrogenase; BCL-2, the activity of B-cell lymphoma-2; CB1, cannabinoid receptor type 1; CB2, cannabinoid receptor type 2; CBCA, cannabichromenic acid; CBD, cannabidiol; CD, clusters of differentiation; cyt c, cytochrome c; ECM, extracellular matrix; ER stress, endoplasmic reticulum stress; FZD, Wnt frizzled receptor; HH-GLI, Hedgehog-GLI; ID1, an inhibitor of DNA binding; THC, Δ9-trans-tetrahydrocannabinol; TRPV2, transient receptor potential cation channel subfamily V member 2. Created with BioRender.com (accessed on 29 August 2022).