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. 2022 Sep 5;11(17):2766. doi: 10.3390/cells11172766

Figure 8.

Figure 8

The mechanism underlying the effect of EVs-150 on chondrocyte repair. (A) qPCR analysis of the miR-150-3p expression in chondrocytes treated with H-FLS–EVs or GW4869. (B) qPCR analysis of the COLII and ACAN mRNA levels in chondrocytes upon H-FLS–EV treatment. (C) The COLII and ACAN protein levels in chondrocytes using WB upon H-FLS–EV treatment. (D) ELISA-based quantitation of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in the chondrocyte culture medium. (E) qPCR analysis of Trim14, NF-κB, and IFN-β mRNA levels. (F) WB analysis of Trim14, NF-κB, and IFN-β protein levels. The data are expressed as mean ± SEM from three independent experiments. **** p < 0.00001, *** p < 0.0001, ** p < 0.01, * p < 0.05.