Table 1.
Examples of small molecules targeting MYCN-driven metabolism reprogramming.
| Metabolic Pathway | MYCN Target | Inhibitor |
|---|---|---|
| Glycolysis | HK2 [64] | 2-Deoxy-D-Glucose (2-DG) [168,169] Benitrobenrazide [170] |
| LDHA [64] | GNE-140 [171] FX11 [172,173] Galloflavin [174] |
|
| Glutamine metabolism | GLS2 [95] | Compound 968 [175] |
| Serine-Glycine synthesis | PHGDH [80] | NCT503 [176] CBR-5884 [177] PKUMDL-WQ-2101 [178] PH-755 [179] |
| SHMT2 [80] | SHIN2 [180] AGF347 [181] |
|
| Nucleotide synthesis | Glutamine amidotransferases (PPAT, PFAS, GMPS, CAD, and CTPS1/2) [96] | 6-diazo-5-oxo-L-norleucine (DON) [182] |
| PPAT [96] | 6-Mercaptopurine [183] | |
| IMPDH [96] | VX-944 [184] Tiazofurin [184] FF-10501 [185] |
|
| DHODH [96] | Leflunomide [186,187] Brequinar [188,189] GSK983 [190] |
|
| Lipid metabolism | FATP2 (SLC27A2) [136] | Lipofermata [191,192] Grassofermata (CB5) [136,191] |