TBI |
traumatic brain injury |
PFC |
prefrontal cortex |
HPA |
hypothalamic–pituitary–adrenal |
LC-NE |
locus coeruleus–norepinephrine |
TNF |
tumor necrosis factor |
TLR |
toll-like receptor |
ROS |
reactive oxygen species |
RIPK |
receptor interacting protein kinase |
MLKL |
mixed lineage kinase domain-like |
ACC |
anterior cingulate cortex |
DG |
dentate gyrus |
mPFC |
medial PFC |
dPFC |
dorsolateral PFC |
BLA |
basolateral amygdala |
CeA |
central amygdala |
Glu |
glutamate |
γ-GABA |
γ-aminobutyric acid |
CeL |
centrolateral |
CeM |
centromedial |
snRNA-seq |
single-nucleus RNA sequencing |
CRH |
corticotropin-releasing hormone |
PVN |
paraventricular nucleus |
AVP |
arginine vasopressin |
ACTH |
adrenocorticotropic hormone |
GCs |
glucocorticoids |
MR |
mineralocorticoid receptor |
GR |
glucocorticoid receptor |
CNS |
central nervous system |
PNs |
pyramidal neurons |
PV |
parvalbumin |
SST |
somatostatin |
E/I |
excitatory and inhibitory |
SNARE |
soluble N-ethylmaleimide-sensitive factor attachment protein receptor |
NMDAR |
N-methyl d-aspartate receptor |
AMPAR |
alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor |
DA |
dopamine |
VTA |
ventral tegmental area |
D1R |
D1 receptor |
DEX |
dexamethasone |
FKBP5 |
FK506-binding protein 5 |
CRF |
corticotropin releasing factor |
PTSD |
post-trauma brain injury |
mFPI |
mild fluid-percussion injury |
BDNF |
brain-derived neurotrophic factor |
RS |
restraint stress |
CCI |
controlled cortical injury |
ERS |
endoplasmic reticulum stress |
RUS |
repeated unpredictable stress |
r-mTBI |
repetitive mild TBI |
rcTBI |
repetitive concussive TBI |
ETC |
electron transport chain |
PDH |
pyruvate dehydrogenase |
bTBI |
blast-induced TBI |
CK |
creatine kinase |
NF-H |
neurofilaments-heavy |
NSE |
neuron-specific enolase |
GFAP |
glial fibrillary acidic protein |
VEGF |
vascular endothelial growth factor |
SF |
sleep fragmentation |
HCC |
hair cortisol concentrations |
CHI |
closed head injury |
CVS |
chronic variable stress |
AST |
attentional set-shifting test |
sEPSCs |
spontaneous excitatory postsynaptic currents |
EPM |
elevated plus maze |
5-HTP |
5-hydroxytryptophan |
5-HIAA |
5-hydroxyindoleacetic acid |
CRS |
chronic RS |
BBB |
blood–brain barrier |
TrkB |
tropomyosin-related kinase receptor |
VEGF |
vascular endothelial growth factor |
SN |
substantia nigra |
CUMS |
chronic unpredictable mild stress |
RSDS |
repeated social defeat stress |
MDA |
malondialdehyde |
UCH-L1 |
ubiquitin carboxy-terminal hydrolase L1 |
DTI |
diffusion tensor imaging |
SWI |
susceptibility weighted imaging |
fMRI |
functional MRI |