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. 2022 Aug 23;23(17):9533. doi: 10.3390/ijms23179533

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Esomeprazole dilates human omental arteries obtained from normotensive pregnancies. Wire myograph assessment of arterial reactivity following constriction with the vasoconstrictor U44619 (thromboxane agonist), and treatment with 0.1–100 μmol/L esomeprazole magnesium trihydrate (Eso MTH) and esomeprazole magnesium hydrate (Eso MH), compared with vehicle (A,B). Data presented as percentage of relaxation (% relaxation) following normalisation to the maximum relaxation to bradykinin, demonstrating both Eso MTH and Eso MH significantly relaxed vessels at the highest concentration (100 μmol/L) (A). The maximum relaxation induced by Eso MTH or Eso MH show no significant difference to vehicle treated vessels (B). Data expressed as mean ± SEM; significance is indicated by the following ** p < 0.01, **** p < 0.0001 (n = 7). The x-axis is in log10 scale.