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. 2022 Sep 4;11(17):2700. doi: 10.3390/foods11172700

Table 1.

Identification of mice serum metabolites after administering Auricularia auricula polysaccharides.

No. Metabolites Sub Class VIP Value p Value Experimental m/z Molecular Formula HMDB ID KEGG ID AAP vs. ND
1 Polyoxyethylene (600) monoricinoleate Fatty alcohols 2.286 0.001 341.3039 C21H40O3 HMDB0032476 --- ↑
2 Solasodine Steroidal alkaloids 2.286 0.004 414.3364 C27H43NO2 HMDB0035282 C10822 ↓
3 Guanidoacetic acid Amino acids, peptides, and analogues 2.240 0.001 118.0612 C3H7N3O2 HMDB0000128 C00581 ↑
4 Epidermin Carbohydrates and carbohydrate conjugates 2.194 0.020 262.1273 C11H19NO6 HMDB0034777 ↑
5 (R)-Dihydromaleimide Pyrrolines (Class) 2.094 0.005 100.0397 C4H5NO2 HMDB0030276 --- ↑
6 (R)-Pelletierine Piperidines (Class) 2.053 0.041 142.1224 C8H15NO HMDB0030324 ↑
7 Indoxyl sulfate Arylsulfates 2.031 0.006 214.0163 C8H7NO4S HMDB0000682 --- ↑
8 3-(5-Methyl-2-furanyl)butanal Heteroaromatic compounds (Class) 2.016 0.047 153.0907 C9H12O2 HMDB0036169 --- ↑
9 2-Acetyl-3,6-dimethylpyrazine Carbonyl compounds 1.981 0.008 151.0861 C8H10N2O HMDB0039998 --- ↑
10 Indoxyl Hydroxyindoles 1.970 0.010 134.0598 C8H7NO HMDB0004094 C05658 ↑
11 4,5-Dihydropiperlonguminine Benzodioxoles (Class) 1.957 0.025 276.1587 C16H21NO3 HMDB0041488 --- ↑
12 Perlolyrine Harmala alkaloidal (Class) 1.915 0.020 265.0966 C16H12N2O2 HMDB0030327 C09231 ↑
13 N-Nitroso-pyrrolidine Pyrrolidines (Class) 1.741 0.037 101.0712 C4H8N2O HMDB0031642 C19285 ↑
14 Citrulline Amino acids, peptides, and analogues 1.734 0.043 176.1025 C6H13N3O3 HMDB0000904 C00327 ↑
15 L-Lysine Amino acids, peptides, and analogues 1.667 0.040 147.1125 C6H14N2O2 HMDB0000182 C00047 ↑
16 (±)-Metalaxyl Amino acids, peptides, and analogues 1.648 0.037 280.1532 C15H21NO4 HMDB0031802 C10947 ↑
17 PC(14:0/14:0) Glycerophosphocholines 1.625 0.049 678.5077 C36H72NO8P HMDB0007866 C00157 ↓
18 Ornithine Amino acids, peptides, and analogues 1.614 0.047 133.0969 C5H12N2O2 HMDB0000214 C00077 ↑
19 Linoleamide Fatty amides 1.361 0.050 280.2626 C18H33NO HMDB0062656 --- ↑
20 Sphingosine Amines 1.358 0.036 300.2883 C18H37NO2 HMDB0000252 C00319 ↑
21 Xanthosine Purine nucleosides (Class) 2.569 0.000 283.0687 C10H12N4O6 HMDB0000299 C01762 ↑
22 3-Methoxy-4-hydroxyphenylethyleneglycol sulfate Arylsulfates 2.301 0.000 263.0233 C9H12O7S HMDB0000559 --- ↑
23 (-)-Matairesinol Tetrahydrofuran lignans 2.274 0.000 357.1350 C20H22O6 HMDB0035698 C10682 ↓
24 Dimethylglycine Amino acids, peptides, and analogues 2.183 0.020 102.0551 C4H9NO2 HMDB0000092 C01026 ↑
25 Isokobusone Alcohols and polyols 2.156 0.003 221.1548 C14H22O2 HMDB0036791 --- ↑
26 Indoxyl sulfate Arylsulfates 2.146 0.002 212.0020 C8H7NO4S HMDB0000682 --- ↑
27 12-Oxo-2,3-dinor-10,15-phytodienoic acid Eicosanoids 2.134 0.000 263.1658 C16H24O3 HMDB0032090 --- ↑
28 Eicosapentaenoic acid Fatty acids and conjugates 2.078 0.006 301.2173 C20H30O2 HMDB0001999 C06428 ↓
29 D-Malic acid Beta hydroxy acids and derivatives 2.065 0.004 133.0134 C4H6O5 HMDB0031518 C00497 ↑
30 Phenylacetylglycine Amino acids, peptides, and analogues 2.046 0.005 192.0662 C10H11NO3 HMDB0000821 C05598 ↑
31 trans-Aconitic acid Tricarboxylic acids and derivatives 2.019 0.007 173.0085 C6H6O6 HMDB0000958 C02341 ↑
32 Adipic acid Lipids and lipid-like molecules 2.005 0.013 145.0497 C6H10O4 HMDB0000448 C06104 ↑
33 Benzoic acid Benzoic acids and derivatives 1.991 0.006 121.0285 C7H6O2 HMDB0001870 C00539 ↑
34 D-Ribose Carbohydrates and carbohydrate conjugates 1.988 0.008 149.0447 C5H10O5 HMDB0000283 C00121 ↓
35 L-Lysine Amino acids, peptides, and analogues 1.951 0.007 145.0974 C6H14N2O2 HMDB0000182 C00047 ↑
36 Capric acid Fatty acids and conjugates 1.941 0.007 171.1384 C10H20O2 HMDB0000511 C01571 ↑
37 (10E,12Z)-(9S)-9-Hydroperoxyoctadeca-10,12-dienoic acid Lineolic acids and derivatives 1.930 0.016 311.2235 C18H32O4 HMDB0062434 C14827 ↑
38 Sedoheptulose Carbohydrates and carbohydrate conjugates 1.921 0.009 209.0662 C7H14O7 HMDB0003219 C08355 ↓
39 D-Alanine Amino acids, peptides, and analogues 1.918 0.015 88.0396 C3H7NO2 HMDB0001310 C00133 ↑
40 Succinic acid Dicarboxylic acids and derivatives 1.917 0.020 117.0184 C4H6O4 HMDB0000254 C00042 ↑
41 12-Hydroxydodecanoic acid Medium-chain hydroxy acids and derivatives 1.876 0.023 215.1653 C12H24O3 HMDB0002059 C08317 ↑
42 Citrulline Amino acids, peptides, and analogues 1.800 0.034 174.0877 C6H13N3O3 HMDB0000904 C00327 ↑
43 2-Hydroxy-3-methylbutyric acid Fatty acids and conjugates 1.775 0.033 117.0547 C5H10O3 HMDB0000407 --- ↑
44 L-Pipecolic acid Amino acids, peptides, and analogues 1.731 0.029 128.0707 C6H11NO2 HMDB0000716 C00408 ↑
45 Glyceraldehyde Carbohydrates and carbohydrate conjugates 1.694 0.039 89.0233 C3H6O3 HMDB0001051 C02154 ↑
46 Deoxyinosine Purine 2′-deoxyribonucleosides 1.682 0.020 251.0791 C10H12N4O4 HMDB0000071 C05512 ↓
47 Hippuric acid Benzoic acids and derivatives 1.656 0.006 178.0505 C9H9NO3 HMDB0000714 C01586 ↑
48 Pentadecanoic acid Fatty acids and conjugates 1.655 0.041 241.2176 C15H30O2 HMDB0000826 C16537 ↑
49 Phenylglyoxylic acid Benzoyl derivatives 1.644 0.005 149.0236 C8H6O3 HMDB0001587 C02137 ↑
50 Chenodeoxycholic acid Lipids and lipid-like molecules 1.622 0.044 391.2871 C24H40O4 HMDB0000518 C02528 ↑
51 Threonic acid Carbohydrates and carbohydrate conjugates 1.576 0.046 135.0291 C4H8O5 HMDB0000943 C01620 ↑
52 1,11-Undecanedicarboxylic acid Fatty acids and conjugates 1.463 0.049 243.1605 C13H24O4 HMDB0002327 --- ↑
53 2-Hydroxystearic acid Fatty acids and conjugates 1.452 0.039 299.2592 C18H36O3 HMDB0062549 C03045 ↑
54 2-Hydroxyethanesulfonate Organosulfonic acids and derivatives 1.303 0.029 124.9904 C2H6O4S HMDB0003903 C05123 ↓

ND = normal diets; AAP = Auricularia auricula polysaccharides. VIP = Variable importance projection; ↑ = up-regulated; ↓ =down-regulated.