. 2022 Aug 24;23(17):9591. doi: 10.3390/ijms23179591

Table 2.

Correlation between IGF-2 and variables.

Protein/Group/Coefficient			Variables
Protein/Group/Coefficient			PANSS-P	PANSS-N	PANSS-G	PANSS-T	SAAS	Glucose (mg/dL)	TC¹ (mg/dL)	TG² (mg/dL)	Albumin (g/dL)
IGF-2 (ng/mL)	FE (n = 15)	r	0.003	−0.314	−0.286	−0.282	−0.336	0.002	−0.674	0.003	−0.147
	FE (n = 15)	p	0.991	0.255	0.301	0.308	0.241	0.993	0.016 *	0.992	0.648
	FE_1 (n = 9)	r	0.745 ^s	0.862 ^s	0.445 ^s	0.767 ^s	-	-	-	-	-
	FE_1 (n = 9)	p	0.021 *	0.003 *	0.230	0.016 *	-	-	-	-	-
	∆FE (n = 9)	r	0.800 ^s,%↓	0.150 ^{s, %↓}	0.117 ^{s, %↓}	0.533 ^{s, %↓}	-	-	-	-	-
	∆FE (n = 9)	p	0.014 *	0.708	0.776	0.148	-	-	-	-	-
	ME (n = 40)	r	0.135 ^s	0.162	−0.035	0.075	0.026 ^s	0.08	0.054	0.142	0.160
	ME (n = 40)	p	0.407	0.318	0.829	0.644	0.879	0.673	0.788	0.479	0.435
	ME_R (n = 19)	r	0.226	0.168	−0.090	0.125	−0.271	0.269	−0.275 ^s	0.015	0.347
	ME_R (n = 19)	p	0.353	0.491	0.714	0.609	0.277	0.314	0.342 ^s	0.958	0.224
	ME_NR (n = 21)	r	−0.085	0.257 ^s	0.008	0.049	0.259	−0.258 ^s	0.450	0.284	−0.04
	ME_NR (n = 21)	p	0.715	0.261 ^s	0.974	0.834	0.270	0.374 ^s	0.123	0.347	0.891
	ME_A (n = 16)	r	−0.084 ^s	−0.169	−0.273	−0.235	0.095 ^s	−0.466 ^s	0.138	0.110	0.201
	ME_A (n = 16)	p	0.757 ^s	0.530	0.307	0.381	0.748 ^s	0.108 ^s	0.653	0.720	0.491
	ME_T (n = 23)	r	0.267	0.256 ^s	0.141	0.296	−0.008 ^s	0.219	−0.007	0.207	0.094
	ME_T (n = 23)	p	0.217	0.238 ^s	0.522	0.170	0.971 ^s	0.416	0.983	0.498	0.770

^s Spearman’s correlation coefficient, * p-value < 0.05. Coefficient values range from 1 to −1; the closer the coefficient to extreme values, the stronger the correlation between variables. A positive correlation indicates that both values vary in the same direction. A negative correlation indicates an inverse variation. Pearson’s correlation coefficient (r_p) was employed when data followed a normal distribution (Shapiro–Wilk; p > 0.05). FE: First Episode drug-naïve patients, FE_1: First Episode group after treatment, ∆FE: Protein difference between FE_1 and FE (∆FE = FE_1–FE), ^%^↓: indicates PANSS percentage reduction calculated as (FE_1–FE)/FE × 100, ME: multiple or chronic patients, ME_R: ME patients who had previously responded to treatment, ME_NR: ME patients who had not responded to treatment, ME_A: ME who had abandoned treatment at least 1 month before the psychotic episode took place, and ME_T: ME who had been following treatment until the psychotic episode took place. ¹ TC: total cholesterol, ² TG: total triglycerides.