Table I.
Tools used to assess signs, symptoms, and quality of life in atopic dermatitis trials
| Clinical tool | MCID | Skin lesions | Pruritus | Sleep | Quality of life |
|---|---|---|---|---|---|
| IGA (3) | n/a | ✓ | |||
| EASI (4) | 6.6 | ✓ | |||
| SCORAD (4, 5) | 8.7 | ✓ | ✓ | ✓ | |
| Pruritus NRS (6) | 2–4 | ✓ | |||
| POEM (4, 7) | 4 | ✓ | ✓ | ✓ | |
| DLQI (8, 9)a | 4 | ✓ | ✓ |
a
DLQI question 1 includes itch; however, this is mixed with other symptoms (Over the last week, how itchy, sore, painful, or stinging has your skin been?)
DLQI: Dermatology Life Quality Index; EASI: Eczema and Severity Index; IGA: Investigator’s Global Assessment; MCID: minimum clinically important difference; n/a: not applicable; NRS: numerical rating scale; POEM: Patient-Oriented Eczema Measure; SCORAD: SCORing Atopic Dermatitis; ✓: measured by assessment tool.