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Design of FAK-targeting PROTACs. (A) Molecular docking model of compound 1 with FAK protein (PDB ID: 3BZ3) and the co-crystal binding modes of Pomalidomide (PDB ID: 4CI3). Piperazine fragment of 1 with CRBN E3 ligase ligand to develop FAK PROTACs by linkers. (B) FAK-targeting PROTACs including three parts: FAK Ligand, Linker, and CRBN Ligand.
