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Synthesis of compound 1. Reagents and conditions: (a) N-methylmethanesulfonamide, Cs2CO3, CH3CN, 80 °C, 82.6% yield; (b) BH3 (2 M in THF), anhydrous THF, 60 °C, 47.9% yield; (c) tert-butyl 4–(4-aminophenyl)piperazine-1-carboxylate, ZnBr2, TEA, t-BuOH/DCE, 0 °C, 72.3% yield; (d) a30, DIPEA, 1,4-dioxane, 100 °C, 81.3%; e) CF3COOH, CH2Cl2, 25 °C, 93.6% yield.
