Table 2.

COVID-19 drug research on lung organoids.

Drugs/Compounds	Organoids Model	Brief Description	Ref.
Remdesivir	Human airway organoids, Human alveolar organoids	Inhibit virus replication and infection, Inhibit virus replication	[73] [42]
Camostat	Human airway organoids, Human lung organoids, Human alveolar organoids	Inhibit virus infection, No inhibition effects	[74] [24] [42]
Dutasteride	Human alveolar organoids	Decrease ACE2 levels and inhibit virus infection	[73]
Finasteride	Human alveolar organoids	Decrease ACE2 levels and inhibit virus infection	[73]
Ketoconazole	Human alveolar organoids	Decrease ACE2 levels and inhibit virus infection	[75]
Bestatin	Human alveolar organoids; Human airway organoids	No inhibition effects	[42]
Imatinib	Human alveolar organoids	Inhibit virus entry	[23]
Nafamostat	Human alveolar organoids	Inhibit virus infection	[24]
Quinacrine dihydrochloride (QNHC)	Human alveolar organoids	Inhibit virus infection	[23]
Mycophenolic acid (MPA)	Human alveolar organoids	Inhibit virus infection	[23]
25-hydrocholesterol	Human alveolar organoids	Inhibit virus entry	[76]
Hydroxychloroquine	Human alveolar organoids	Inhibits virus replication and infection	[73]
EK1 peptide	Human alveolar organoids	Inhibits virus infection	[24]
Aloxistatin (E-64d)	Human alveolar organoids Human airway organoids	No inhibition effects	[77,78]
EIDD-2801	Human alveolar organoids; Human airway organoids	Inhibit virus replication and infection	[42,79]
Neutralizing antibodies (C86)	Human alveolar organoids; Human airway organoids	Inhibit virus replication	[42]
Humanized COVID-19 decoy antibody	Human airway organoids	Inhibit virus entry and infection	[70]
IFNB1	Human alveolar organoids, Human airway organoids	Inhibits virus replication and infection, No inhibition effects	[73]
EIDD-2801	Human alveolar organoids; Human airway organoids	Inhibit virus replication and infection	[42,79]
IFNα	Human alveolar organoids	Inhibits virus replication	[68]
IFNγ	Human alveolar organoids	Inhibits virus replication	[68]
IFN-λ1	Human airway organoids	Inhibits virus replication and infection	[65]