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. 2022 Sep 5;11(17):2763. doi: 10.3390/cells11172763

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the signaling pathways affected by IRI during organ preservation. ↓: decrease; ↑: increase; AMPK: AMP-activated protein kinase; ANT: adenine nucleotide translocase; ATF: activating transcription factor; ATG7: autophagy-related gene 7; ATP: adenosine triphosphate; Ca²⁺: calcium ion; CHOP: C/EBP homologous protein; CytC: cytrochrome C; ER: endoplasmic reticulum; FKBP: FK506-binding protein; INFγ: interferon-gamma; iNOS: inducible nitric oxide synthase; IL1: interleukin-1; IRE1: inositol-requiring enzyme 1; LC3B: light chain 3 B; mPTP: mitochondrial permeability transition pore; NF-AT: nuclear factor of activated T-cells; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; NO: nitric oxide; O₂^°− ion: superoxide ion; OH^-: hydroxide ion; PERK: protein kinase RNA-like ER kinase; ROS: reactive oxygen species; TNF: tumor necrosis factor; VDAC: voltage-dependent anionic channel.