TABLE 2.
The SimRFlow output parameters returned for each compound. These parameters can be referred to in the plotting functions of the data visualisation module.
| Output parameters | Units |
|---|---|
| AUC | ng.hr/mL or μM.hr |
| AUC infinity | ng.hr/mL or μM .hr |
| C max (all 10 tissue types) | ng/mL or μM |
| T max (in blood plasma) | hr |
| Half life | hr |
| Absorption rate constant (k a) | hr −1 |
| Predicted V ss | L/kg |
| Predicted f u | dimensionless |
| Predicted BP ratio | dimensionless |
| Fraction absorbed by enterocytes (f a) a | dimensionless |
| Fraction escaping gut wall metabolism(f g) a | dimensionless |
| Fraction escaping hepatic metabolism (f h) a | dimensionless |
| Accumulation index | dimensionless |
| GFR | ml/min/1.73 m2 |
| Age | Years |
| Body weight (BW) | Kg |
| Body surface area (BSA) | m 2 |
| Total systemic clearance (CL tot ) | L/hr |
| Total hepatic intrinsic clearance (CL H ) | L/hr |
| Total renal intrinsic clearance (CL R ) | L/hr |
aThe fraction of the drug at different stages of absorption.