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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Nano Res. 2021 Oct 12;15(3):2300–2314. doi: 10.1007/s12274-021-3813-1

Figure 2.

Figure 2

PBNP-PTT effectively treats local but not distal SM1 melanoma in vivo. (a)–(b) Effect of PBNP-PTT on tumor growth and survival. Tumor-bearing mice were left untreated (CTRL) or treated with PBNP-PTT. (a) Tumor growth observed in the treatment groups. (b) Survival of tumor-bearing animals post-treatment and rechallenge. n = 4/group, **p < 0.01. (c)–(f) Effect of PBNP-PTT on tumor growth and survival in a two tumor model. Tumor-bearing mice were left untreated (CTRL) or treated with PBNP-PTT or PBNP-PTT + aPD-1. When used, PBNP-PTT was administered to only one (“primary”) tumor, and the other (“secondary”) tumor was left untreated. Tumor growth observed in mice treated with (c) CTRL, (d) PBNP-PTT, and (e) PBNP-PTT + aPD-1. Solid lines represent the primary (treated) tumor, dashed lines represent the secondary (untreated) tumor. (f) Survival of tumor-bearing animals post-treatment. n = 4/group; **p < 0.01, ns: not significant.