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. Author manuscript; available in PMC: 2022 Sep 8.
Published in final edited form as: Lancet Oncol. 2021 Dec 11;23(1):149–160. doi: 10.1016/S1470-2045(21)00589-1

Figure 2: Prognostic value of RCB score and RCB class in the overall pooled analysis cohort.

Figure 2:

Plots of log relative hazard rate for event-free survival events (A) and distant relapse-free survival events (B) as a function of RCB score. Splines approximation of RCB with two degrees of freedom was used to allow for non-linear effect. A log linear increase in relative hazard rate implies that the hazard ratio associated with change in RCB remains constant over the range of RCB. Thresholds for corresponding RCB classes (RCB-0 to RCB-3) are shown for reference (vertical dashed lines). Vertical bars represent all RCB scores recorded on a continuous scale. Kaplan-Meier plots of event-free survival (C) and distant relapse-free survival (D) stratified by RCB class. Crosses denote patients censored. RCB=residual cancer burden. pCR=pathological complete response.