Table 2.
Compound | Origin | Using Part | Other Bioactivities | Target Phase | Experimental Model | Type of Wound | Ref. |
---|---|---|---|---|---|---|---|
Quercetin | Plant (Oxytropis falcata Bunge) |
Fruits | Anti-inflammatory Anti-infection |
Inflammation Proliferation Remodeling |
Mice | Excision | [63] |
Resveratrol | Plant | N/A | Anti-inflammatory Anti-bacterial |
Inflammation Proliferation |
HUVE cells Rat |
Burn injury | [149] |
Catechin | Plant (Green tea) |
N/A | Anti-bacterial Anti-inflammatory Pro-angiogenic |
Inflammation | Mice | Chronic diabetic wound | [65] |
Catechin | N/A | N/A | N/A | N/A | Mouse NIH/3T3 fibroblast cell | N/A | [200] |
Luteolin | Plant | N/A | Anti-inflammatory Anti-allergenic |
Inflammation Proliferation |
Rat | Excision | [42] |
Syringic acid | Plant | Fruits | Anti-inflammatory Anti-microbial Anti-adipogenic |
Inflammation Proliferation Remodeling |
Rat | Incision diabetic wound | [133] |
Metformin | N/A | N/A | Anti-hypoglycemic | Inflammation Proliferation |
Mice | Diabetic wounds | [87] |
Naringenin | Plant | Citrus fruits | Anti-inflammatory | Proliferation Inflammation |
Rat | Thermally-induced skin damage | [201] |
Galic acid | Plant | Fruits Leaves Flower |
Anti-inflammatory Analgesic |
Inflammation Proliferation |
HaCaT MEF HF21 cells |
Hyperglucidic conditions | [61] |
Ferulic acid | Plant (vegetables, cereals, coffee) |
Seed Fruits |
Anti-inflammatory Antimicrobial |
Inflammation Proliferation |
Rat | Excision diabetic wounds | [84] |
Curcumin | Plant | Turmeric | Anti-inflammatory | Inflammation Proliferation |
Rat | Excision | [82] |
Curcumin | Plant (Curcuma longa) |
Turmeric | Anti-inflammatory Anti-infective |
Inflammation | Rat | Excision | [57] |
Curcumin | Plant | Turmeric | Anti-inflammatory | Inflammation | Human keratinocytes and fibroblasts | H2O2 condition | [60] |
Curcumin | Plant (Curcuma longa) |
Turmeric | N/A | Inflammation | Human keratinocytes | Hypoxanthine/xanthine oxidase injury | [202] |