Table 4.
Compounds with collagen promotion.
| Compound | Origin | Using Part | Other Bioactivities | Target Phase | Experimental Model | Type of Wound | Ref. |
|---|---|---|---|---|---|---|---|
| Honey | Animal (Bee) |
Honey | Anti-bacterial | Proliferation | Rat | Excision | [253] |
| Calendula officinalis extract | Plant (Calendula officinalis) |
Flower | Anti-bacterial | Proliferation | Rat | Excision | [98] |
| Saponins | Plant (Panax Notoginseng) |
Root Rhizome |
Anti-inflammation Anti-oxidant Anti-apoptosis Anti-coagulation |
Remodeling | Hypertrophic scar fibroblast | N/A | [165] |
| Cryptotanshinone | Plant (Salvia miltiorrhiza Bge.) |
N/A | Anti-inflammatory Anti-oxidative Anti-bacterial |
Remodeling | Diabetic mice | Excision | [49] |
| Bexarotene, Taspine, and 2-hydroxy-1-naphthaldehyde Isonicotinoylhydrazone |
Plant (Daemonorops draco) |
N/A | Anti-bacterial Anti-inflammation |
Inflammation Proliferation |
THP-1, HaCaT, NIH-3T3 cells | N/A | [35] |
| Sesamol | Plant | Sesame oil | Anti-inflammatory Anti-oxidant |
Inflammation Proliferation |
Rat | Diabetic foot ulcer | [86] |
| Astragaloside IV | Plant (Astragali Radix) |
N/A | Anti-inflammatory Anti-oxidative |
Inflammation Proliferation |
Mice | Excision | [108] |
| Polysaccharide APS2-1 | Plant (Astragalus membranaceus) |
Roots | Anti-inflammatory | Inflammation Proliferation |
Mice | Excision | [163] |
| Aloe vera gel | Plant (Aloe vera) |
Leaves | Anti-inflammatory Anti-bacterial Anti-viral Anti-fugal |
Proliferation | Mouse embryonic fibroblasts | N/A | [254] |
| Asiaticoside | Plant (Centella asiatica) |
Aerial parts | Anti-oxidant | Proliferation | Rabbit | Incision | [135] |
| Gallic acid and quercetin | Plant (Glycyrrhiza glabra L.) |
Roots | Anti-inflammatory Anti-bacterial Anti-microbial Antioxidant |
Inflammation Proliferation |
Pig | Excision | [88] |
| Asiatic acid | Plant (Centella asiatica) |
Aerial parts | Anti-oxidative | Proliferation | Rat | Wound burn | [141] |
| β-Glucans | Fungi | N/A | Anti-biotic | Proliferation | Human dermal fibroblasts |
N/A | [255] |
| Alkaloids | Plant (Evolvulus alsinoides) |
Aerial parts | Anti-bacterial Anti-fugal Anti-oxidant |
Proliferation | Rat | Incision | [256] |
| Asiaticoside and madecassoside | Plant (Centella asiatica) |
N/A | Anti-oxidant | Proliferation | Rat | Burn injury | [89] |
| Triterpenes | Plant (Buddleia scordioides) |
Leaves | N/A | Proliferation | Diabetic rat | Incision Excision |
[257] |
| Deoxyelephantopin | Plant (Elephantopus scaber) |
Leaves | Anti-inflammatory | Inflammation Proliferation |
Rat | Incision | [139] |