Fig. 4.

Functional analysis and negative strand bias of viral circRNAs. KEGG pathway and GO enrichment analyses of viral circRNA interacting genes. Only the top 10 enriched terms of the KEGG pathway (a), biological process (BP) (b), molecular function (MF) (c) and cellular component (CC) (d) are shown. The coverage curve of circRNAs on the reference genomes of MERS-CoV (e) and SARS-CoV-2 (f). Genes with known mapped positions in the genome are shown in orange. The pink curve and blue curve show the number of viral circRNAs for which each nucleotide is covered on the plus strand and minus strand, respectively.