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. 2022 Jun 22;8(6):mgen000848. doi: 10.1099/mgen.0.000848

Fig. 5.

Fig. 5.

Long-range cyclization of the viral genome and subgenome. The scatter plot shows the cyclization positions of circRNAs in EBV (a) and MERS-CoV (b). The circRNA, formed by long-range cyclization, is highlighted in red when its length is ≥90 % of the reference genome and in orange when its length is ≥50 % but <90 %. Violin plot of ln(CPM) for EBV (Wilcoxon rank-sum test P=0.018) (c) and MERS-CoV (Wilcoxon rank-sum test P<2×10−16) (d) circRNAs grouped into long (length ≥50 % of the reference genome) and non-long (length <50 % of the reference genome) groups. (e) Scatter plot of the cyclization positions of SARS-CoV-2 circRNAs. The circRNA, formed by long-range cyclization, is highlighted in red when its length is ≥90 % of the reference genome and in orange when its length is ≥50 % but <90 %. (f) Violin plot of ln(CPM) for SARS-CoV-2 circRNAs grouped into long (length ≥50 % of the reference genome) and non-long (length <50 % of the reference genome) groups (Wilcoxon rank-sum test P=0.049).