Figure 1.

Dysfunctional cerebral glucose metabolism is a crucial factor in AD development. Glucose catabolism in AD is directly connected to further negative consequences in AD syndrome development. (A) Schematic representation of defective glucose metabolism in AD and various outcomes. ↑ arrows indicate upregulation and ↓ arrows indicate downregulation. (B) Glucose metabolism forms the bridge between neurotoxicity and cognitive dysfunction in AD. This interconnected Venn diagram describes the scenarios in which AD-related toxicity and cognitive dysfunction appear during AD onset and progression.