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. 2022 Aug 23;23(17):9540. doi: 10.3390/ijms23179540

Figure 6.

Figure 6

(A) The inhibition in the oxidative defense system potentiates Aβ oligomerization and Tau phosphorylation in the diabetic brain. ↓ arrows indicate downregulation. (B) Tau phosphorylation and NFT formation. In a healthy cell, phosphorylated tau protein binds with microtubules (MT) and maintains stability. However, hyperphosphorylation tau aggregates into the NFTs which leads to MT instability. This figure was drawn using BioRender application (https://biorender.com (accessed on 21 June 2022)).