Table 5.
Outcomes by monogenic versus non-monogenic disease.
| Monogenic [n = 17] | Non-monogenic [n = 199] | OR [95% CI] | p-value | |
|---|---|---|---|---|
| H=Hospitalisation | 15 [88.2%] | 139 [69.8%] | 3.24 [0.88, 20.95] | 0.12 |
| ICU hospitalisation | 9 [52.9%] | 13 [6.5%] | 14.54 [4.56, 49.98] | <0.001 |
| G-tubea | 7 [41.2%] | 11 [5.5%] | 11.96 [3.74, 37.82] | <0.001 |
| TPN in hospital | 8 [47.1%] | 23 [11.6%] | 6.80 [2.35, 19.58] | <0.001 |
| TPN at home | 2 [11.8%] | 2 [1.0%] | 13.13 [1.49, 115.98] | 0.01 |
| Surgery | 4 [23.5%] | 37 [18.6%] | 1.35 [0.36, 4.06] | 0.62 |
| 5-ASA exposure | 8 [47.1%] | 164 [82.4%] | 0.19 [0.07, 0.53] | 0.001 |
| 5-ASA failure | 5 [62.5%] | 111 [67.7%] | 0.92 [0.19, 6.62] | 0.93 |
| Anti-TNF exposure | 5 [29.4%] | 111 [55.8%] | 0.33 [0.10, 0.93] | 0.04 |
| Anti-TNF failure | 3 [60.0%] | 56 [50.5%] | 2.57 [0.32, 52.92] | 0.42 |
| Weight z-score <-2 at 3-year follow-up | 2/9 [22.2%] | 9/146 [6.2%] | 3.00 [0.43,13.13] | 0.19 |
| Height z-score <-2 at 3-year follow-up | 4/9 [44.4%] | 12/146[8.2%] | 5.17 [1.30, 17.60] | 0.01 |
| BMI z-score <-2 at 3-year follow-up | 0/9 [0.0%] | 3/146 [2.1%] | n.e. | 1.00 |
| HSCT | 7 [41.2%] | 0 [0.0%] | n.e. | <0.001 |
| Death | 2 [11.8%] | 0 [0.0%] | n.e. | 0.006 |
n.e. = not estimable.
Includes one patient with monogenic disease who had gastrojejunal [GJ] tube.