Table 2.
Patient demographics and clinical information.
| Variables | CD [n = 93] | UC [n = 43] | HD [n = 23] |
|---|---|---|---|
| Age, years, IQR [median, 25% to 75%] | 35 [27 to 44.3] | 36 [21 to 49] | 37 [26 to 50] |
| Male gender, n [%] | 33 [61] | 23 [53] | 22 [55] |
| BMI, kg/m2, IQR [median, 25% to 75%] | 23.43 [19 to 33] | 22.9 [19.9 to 27.5] | |
| Smoking, n [%] | 24 [44] | 7 [16] | |
| Disease duration, IQR [median, 25% to 75%] | 9.01 [3.76 to 15.89] | 7.34 [0.04 to 28.6] | |
| Localisation CD, n [%] L1/L2/L3/L4 | 6 [11]/10 [19]/34 [63]/4 [7] | - | |
| Behaviour CD, n [%] B1/B2/B3 | 19 [37]/17 [33]/15 [30] | - | |
| Extension UC, n [%] E1/E2/E3 | - | 4 [10]/11 [28]/25 [63] | |
| Perianal disease, n [%] | 14 [26] | - | |
| Truelove and Witts score | 40 [93] | ||
| Partial Mayo Score | 42 [98] | ||
| Mayo Endoscopic Score | 30 [70] | ||
| Endoscopic severity, n [%] Remission Mild Moderate Severe |
SES-CD, 54 [55] 28 [52] 10 [19] 11 [20] 5 [9] |
Full Mayo Score, 30 [70] 7 [23] 12 [40] 9 [30] 2 [7] |
|
| Prior surgery, n [%] | 21 [39] | 5 [12] | |
| Immunosuppressive therapy, n [%] | 33 [61] | 16 [37] | |
| Biologic therapy, n [%] | 31 [57] | 28 [65] | |
| Serum sample availability, n [%] | 85 [91] | 40 [93] | 40 [100] |
| Faecal sample availability, n [%] | 76 [82] | 37 [86] | |
| Neutrophil, count, IQR [median, 25% to 75%] | 4.48 [3.41 to 5.48] | 4.43 [3.20 to 5.47] | |
| Leukocytes IQR [median, 25% to 75%] | 7 [5.6 to 8.4] | 6.70 [5.35 to 9.30] | |
| Lymphocytes IQR [median, 25% to 75%] | 1.53 [1.18 to 2.18] | 1.73 [1.29 to 2.44] | |
| Faecal CP, IQR [median, 25% to 75%] | 150 [32.8 to 399] | 308 [138 to 1325] | |
| C-reactive protein, IQR [median, 25% to 75%] | 2.5 [0.85 to 5.85] | 3.1 [0.60 to 8.4] | |
| Albumin, IQR [median, 25% to 75%] | 44.9 [42.2 to 46.8] | 43.9 [40.8 to 52.3] | |
| AST, IQR [median, 25% to 75%] | 23 [19 to 29.5 | 20 [16 to 25] | |
| ALT, IQR [median, 25% to 75%] | 21 [15 to 29] | 19 [14 to 27.5] |
CD, Crohn’s disease; UC, ulcerative colitis; IQR, interquartile range; BMI, body mass index; CP, calprotectin; SES-CD, Simple Endoscopic Score of Severity for CD; AST, aspartate transaminase; ALT, alanine transaminase; HD, healthy donors.