Table 4.

Diagnostic accuracy of CPa9-HNE and faecal CP to differentiate between remission and active disease.

	CPa9-HNE				Faecal CP
	AUC [CI]	SENS % [CI]	SPEC % [CI]	t test [p-value]	AUC [CI]	SENS % [CI]	SPEC % [CI]	t test [p-value]
Remission vs. active
SES-CD	0.68 [0.52 to 0.84]	62 [41 to 80]	86 [69 to 94]	0.0152	0.73 [0.58 to 89]	56 [34 to 75]	88 [69 to 96]	0.0137
Full Mayo	0.78 [0.63 to 0.93]	62 [41 to 80]	94 [73 to 100]	0.0041	0.78 [0.62 to 0.94]	88 [69 to 96]	62 [36 to 82]	0.0031
MES	0.69 [0.51 to 0.88]	48 [26 to 67]	92 [64 to 100]	0.0752	0.64 [0.43 to 0.85]	73 [52 to 87]	64 [34 to 85]	0.302
SES-CDa	0.68 [0.50 to 0.86]	47 [26 to 69]	96 [78 to 100	0.0149	0.72 []	56 [33 to 76]	86 [67 to 95]	0.0264
Full Mayoa	0.82 [0.67 to 0.96	66 [45 to 82]	91 [62 to 100]	0.0036	0.79 [0.64 to 0.96	48 [28 to 90]	91 [62 to 100]	0.0035
MESa	0.74 [0.54 to 0.94]	74 [51 to 88]	80 [38 to 99]	0.22	0.55 [0.21 to 0.89]	79 [56 to 92]	60 [23 to 92]	0.738
Remission vs. moderate/severe
SES-CD	0.82 [0.69 to 0.95]	79 [41 to 80]	86 [73 to 100]	0.0003	0.85 [0.71 to 0.98]	78 [45 to 96]	88 [69 to 96]	0.0043
Full Mayo	0.87 [0.70 to 1.00]	80 [49 to 96]	94 [73 to 100]	0.0004	0.85 [0.71 to 0.98]	42 [19 to 68]	100 [77 to 100]	0.014
MES	0.76 [0.56 to 0.97]	77 [50 to 92]	75 [46 to 91]	0.0328	0.65 [0.30 to 1.00]	93 [70 to 100]	60 [23 to 93]	0.249
SES-CDa	0.85 [0.70 to 1.00]	67 [35 to 88]	95 [78 to 100]	0.0002	0.83 [0.69 to 0.98]	75 [41 to 96]	86 [67 to 95]	0.0090
Full Mayoa	0.94 [0.82 to 1.00]	91 [62 to 100]	91 [62 to 100]	0.0021	0.79 [0.60 to 0.99]	55 [28 to 79]	90 [62 to 99]	0.014
MESa	0.85 [0.67 to 1.00]	67 [39 to 86]	100 [56 to 100]	0.0251	0.63 [0.26 to 0.99]	92 [65 to 100]	60 [23 to 93]	0.235

CP, calprotectin; SES-CD, Simple Endoscopic Score of Severity for CD; MES, Mayo Endoscopic Score; CRP, C-reactive protein; AUC, area under the curve; SENS, sensitivity; SPEC, specificity; CI, confidence interval.

Paired serum and faecal samples.