Fig 10. Multi-layer microcircuit model with three inhibitory neuron types.

(A) Schematic overview of all neuronal populations, external inputs, and main connections. Inhibitory populations are grouped by boxes. In panels A and B, for probabilistic connections, only those with a probability of at least 4% are shown (thin lines: 4 to 8%, thick lines: ≥8%). (B) Detailed L2/3 connectivity between excitatory population and all three inhibitory populations; in panel A these connections are combined in two arrows (from and to the box). (C) Excitatory-inhibitory subnetwork with external inputs depicted with annotations according to the graphical notation in Fig 8. The connectivity is described with the rules “one-to-one” (δ) and “pairwise Bernoulli” (p), and the constraints autapses allowed (A) and multapses prohibited ($\cancel{M}$). The synaptic weights (w) and delays (d) are specified as either constant (i.e., $\overline{w}$) or sampled from lognormal distributions (i.e., $w\sim \mathcal{L}\mathcal{N}$). Interneuron types: somatostatin expressing (SOM), vasoactive intestinal peptide expressing (VIP), parvalbumin expressing (PV).