Table 1.
The list of clustered serum DEPs identified by MCODE.
| MCODE Cluster-ID |
Gene Symbol | MCODE Score | Biological Functions of These Genes |
|---|---|---|---|
| Cluster 1 | Psmb3 | 7.50 | 20S proteasome; Proteasome; Cross-presentation of soluble exogenous antigens (endosomes) |
| Psmb2 | |||
| Psma7 | |||
| Psma6 | |||
| Psma5 | |||
| Psma4 | |||
| Psma1 | |||
| Psmb7 | |||
| Psmb6 | |||
| Psmb5 | |||
| Psmb4 | |||
| Psmb10 | |||
| Psmb1 | |||
| Psma3 | |||
| Psma2 | |||
| Psmb8 | |||
| Cluster 2 | Vgf | 5.06 | Complement and coagulation cascades; Regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs); Post-translational protein phosphorylation |
| Fgb | |||
| Fermt3 | |||
| Fgg | |||
| Serpina1e | |||
| Serpina1a | |||
| Serpinf2 | |||
| Orm3 | |||
| Itih2 | |||
| Igfbp3 | |||
| Igf1 | |||
| Cp | |||
| C4b | |||
| Serping1 | |||
| Apoe | |||
| Cfd | |||
| Cluster 3 | Agxt2 | 1.17 | Small molecule catabolic process; Neutrophil degranulation; Monocarboxylic acid metabolic process |
| Vnn1 | |||
| Sord | |||
| Lamp2 | |||
| Lamp1 | |||
| Fah | |||
| Cluster 4 | Rap1b | 2.00 | Integrin-mediated cell adhesion; Focal adhesion; Rap1 signaling pathway; Cell adhesion mediated by integrin |
| Itgb3 | |||
| Itgb2 | |||
| Itgam | |||
| Itga2b | |||
| Cluster 5 | C8a | 2.00 | Terminal pathway of complement; Complement activation, alternative pathway cytolysis |
| C8b | |||
| C8g | |||
| Hc | |||
| C9 | |||
| Cluster 6 | Apom | 1.50 | Plasma lipoprotein particle remodeling; Protein–lipid complex remodeling; Protein-containing complex remodeling |
| Pltp | |||
| Apoh | |||
| Apoa4 | |||
| Cluster 7 | Krt12 | 1.50 | Epidermis development; Formation of the cornified envelope; Keratinization |
| Krt76 | |||
| Krt2 | |||
| Krt10 | |||
| Cluster 8 | Aldob | 1.50 | Carbon metabolism; Hexose metabolic process; Monosaccharide metabolic process |
| H6pd | |||
| Pgam2 | |||
| Eno1 | |||
| Cluster 9 | Dstn | 1.00 | Actin cytoskeleton organization; Actin-filament-based process |
| Pfn1 | |||
| Cap1 |