Table 3.
The list of clustered hepatic DEPs identified by MCODE.
| MCODE Cluster-ID | Gene Symbol | MCODE Score | Biological Functions of These Genes |
|---|---|---|---|
| Cluster 1 | Hspa13 | 4.33 | Protein folding; ER-localized multiprotein complex, in absence of Ig heavy chains ER-localized multiprotein complex, Ig heavy chain-associated; |
| Eif4b | |||
| Dnajc25 | |||
| Rps27l | |||
| Nudt7 | |||
| Nop56 | |||
| Rpl11 | |||
| Rsl1d1 | |||
| Sdf2l1 | |||
| Dnaja4 | |||
| Rps28 | |||
| Sec61a1 | |||
| Pnrc2 | |||
| Rps7 | |||
| Rps3a1 | |||
| Rbm3 | |||
| Ppib | |||
| Sqstm1 | |||
| Hsp90aa1 | |||
| Hspa1b | |||
| Hsph1 | |||
| Hspa5 | |||
| Pdia3 | |||
| Fbl | |||
| Pdia4 | |||
| Hyou1 | |||
| Cluster 2 | Cyp2c23 | 6.62 | Retinol metabolism; Chemical carcinogenesis—DNA adducts; Xenobiotic metabolic process |
| Cyp2c70 | |||
| Gstt3 | |||
| Gstk1 | |||
| Ugt2a3 | |||
| Cyp2u1 | |||
| Mgst3 | |||
| Erg28 | |||
| Cyp3a25 | |||
| Aldh1a7 | |||
| Hsd3b5 | |||
| Gstp1 | |||
| Gsta2 | |||
| Gsta1 | |||
| Cyp4a14 | |||
| Cyp4a10 | |||
| Cyp2b9 | |||
| Cyp2b10 | |||
| Cyp26a1 | |||
| Cyp1a2 | |||
| Cluster 3 | Dnajc3 | 4.50 | Post-translational protein phosphorylation; Regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs); Plasma lipoprotein remodeling |
| Pdia6 | |||
| Apoa5 | |||
| Hsp90b1 | |||
| Serpina1e | |||
| Serpina1b | |||
| Calu | |||
| Apoa2 | |||
| Alb | |||
| Cluster 4 | Aldob | 1.90 | Glycolysis/gluconeogenesis; Glucose metabolism; Gluconeogenesis |
| H1f5 | |||
| Maoa | |||
| H2ax | |||
| H1f3 | |||
| Fbp1 | |||
| Eno3 | |||
| Bpgm | |||
| Aldoc | |||
| Cluster 5 | Ttll3 | 1.25 | GnRH secretion; Bacterial invasion of epithelial cells; RHO GTPase effectors |
| Arpc1a | |||
| Trpc4 | |||
| Prkca | |||
| Itpr2 | |||
| Cdh1 | |||
| Casp3 | |||
| Arpc1b | |||
| Cluster 6 | Abcb8 | 1.43 | Supramolecular fiber organization; Actin cytoskeleton organization; Actin filament-based process |
| Crip2 | |||
| Lima1 | |||
| Abcb10 | |||
| Ppl | |||
| Gas2 | |||
| Cluster 7 | Acss3 | 2.50 | Valine, leucine and isoleucine degradation; Propanoate metabolism; Carboxylic acid catabolic process |
| Abat | |||
| Aldh1b1 | |||
| Hadh | |||
| Acadm | |||
| Cluster 8 | Txndc5 | 2.00 | Neutrophil degranulation |
| Dpp7 | |||
| Orm2 | |||
| Fabp5 | |||
| Cluster 9 | Spcs2 | 1.80 | Signal peptide processing; Synthesis, secretion, and deacylation of ghrelin; Protein export |
| Sec11c | |||
| Sec11a | |||
| Alpl | |||
| Cluster 10 | Rpn1 | 1.50 | Protein N-linked glycosylation; Macromolecule glycosylation; Protein glycosylation |
| Ostc | |||
| Stt3a | |||
| Cluster 11 | Acot4 | 1.50 | Peroxisomal protein import; Protein localization; Fatty acid metabolism |
| Acot3 | |||
| Acot1 | |||
| Cluster 12 | Akr1d1 | 1.50 | Steroid hormone biosynthesis; Androgen metabolic process; Steroid catabolic process |
| Hsd17b6 | |||
| Hsd17b2 | |||
| Cluster 13 | Necap1 | 1.50 | Clathrin-mediated endocytosis; Cargo recognition for clathrin-mediated endocytosis; Membrane Trafficking |
| Egfr | |||
| Cttn | |||
| Cluster 14 | C8b | 1.50 | Terminal pathway of complement Complement activation, alternative pathway; Cytolysis |
| C8g | |||
| Hc |