Table 5.
The IC50 values of 3, 4, 5, 6, 7, 8 against 5637, LNCaP, and A375 cells. Data are expressed as the mean ± SD from at least three independent experiments.
| Compound | IC50 [nM] | |||||
|---|---|---|---|---|---|---|
| 5637 | LNCaP | A375 | ||||
| 0 J/cm2 | 10 J/cm2 | 0 J/cm2 | 10 J/cm2 | 0 J/cm2 | 10 J/cm2 | |
| 3 | >250 | 8.01 ± 2.12 | >250 | 49.71 ± 11.55 | >1000 | 754.69 ± 145.56 |
| 4 | >250 | 32.13 ± 3.86 | >1000 | 44.91 ± 1.98 | >1000 | 250.59 ± 64.51 |
| 5 | >1000 | 79.71 ± 7.08 | >1000 | 106.00 ± 26.27 | >1000 | 578.01 ± 25.44 |
| 6 | >250 | 15.56 ± 3.50 | >250 | 48.63 ± 13.21 | >1000 | 284.56 ± 83.21 |
| 7 | >1000 | 149.92 ± 42.12 | >1000 | 557.75 ± 104.99 | >1000 | >1000 |
| 8 | >1000 | 247.94 ± 45.45 | >1000 | 333.53 ± 116.33 | >1000 | >1000 |