Table 1.
Absorption of erythritol.
| A: 10 g Erythritol (n = 11) |
B: 25 g Erythritol (n = 12) |
C: 50 g Erythritol (n = 12) |
p-Values | |
|---|---|---|---|---|
| AUC180 (mM·min) | 201.0 ± 12.7 | 450.6 ± 29.3 | 707.1 ± 53.9 | A vs. B: p < 0.001 A vs. C: p < 0.001 B vs. C: p < 0.001 |
| Cmax (µM) | 1810.6 ± 124.6 | 3676.9 ± 251.2 | 5404.3 ± 450.6 | A vs. B: p < 0.001 A vs. C: p < 0.001 B vs. C: p = 0.001 |
| Absorption rate ka (min−1) | 0.126 ± 0.183 | 0.374 ± 0.257 | 0.036 ± 0.031 | All n.s. |
| Absorption half-life tka,1/2 (min) | 5.40 ± 1.16 | 4.88 ± 0.86 | 14.23 ± 2.66 | A vs. B: n.s. A vs. C: p = 0.004 B vs. C: p = 0.002 |
| Elimination rate k10 (min−1) | 0.008 ± 0.002 | 0.008 ± 0.001 | 0.002 ± 0.001 | All n.s. |
| Elimination half-life tka,1/2 (min) | 46.09 ± 5.68 | 51.41 ± 3.62 | 42.69 ± 5.24 | All n.s. |
| Volume of distribution V1 (L) | 38.50 ± 4.27 | 37.74 ± 2.43 | 50.95 ± 5.62 | All n.s. |
Data are expressed as mean ± SEM and reported from baseline. Linear mixed effect model analysis with Šidak correction for multiple testing. AUC180: area under the curve from 0 to 180 min, Cmax: maximum plasma concentration, n.s.: not significant.