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. 2022 Sep 1;23(17):9927. doi: 10.3390/ijms23179927

Table 1.

LD50 values of n-acyl piperidine compounds.

graphic file with name ijms-23-09927-i001.jpg
N Substituents (R1, R2, R3 and R4) LD50 (mM) [a] pLD 50 [b]
1 R1: -(CH2)6CH3; R3: -CH2C6H5 (pivot molecule) 10.23 4.99
2 R1: -CH2C6H11; R4: -CH2C6H5 15.49 4.81
3 R1: -(CH2)8CHCH2; R4: -CH2C6H5 23.44 4.63
4 R1: -(CH2)2C6H11; R4: -CH2C6H5 24.55 4.61
5 R1: -(CH2)10CH3; R2: -CH3 32.36 4.49
6 R1: -CH2O2C6H5(CH)3 35.48 4.45
7 R1: -(CH2)10CH3; R4: -CH3 41.69 4.38
8 R1: -(CH2)8CHCH2; R4: -CH2C6H5 45.71 4.34
9 R1: -(CH2)8CH3; R4: -CH3 51.29 4.29
10 R1: -CH2C6H10CH3; R3: -CH3 57.54 4.24
11 R1: -(CH2)3C6H11; R4: -CH3 58.88 4.23
12 R1: -C6H11; R4: -CH3 79.43 4.10
13 R1: -(CH2)8CH3; R2: -CH3 93.33 4.03
14 R1: -(CH2)8CHCH2; R2: -CH2C6H5 95.50 4.02
15 R1: -(CH2)8CHCH2; R4: -CH3 97.72 4.01
16 R1: -(CH2)5CH3; R3: -CH3 102.33 3.99
17 R1: -(CH2)2C6H11; R3: -CH3 123.03 3.91
18 R1: -CH2C6H11; R3: -CH3 123.03 3.91
19 R1: -CH2C6H11; R2: -CH3 125.89 3.90
20 R1: -(CH2)2C5H9; R2: -CH2CH3 128.82 3.89
21 R1: -(CH2)8CHCH2; R3: -CH3 128.82 3.89
22 R1: -(CH2)5CH3; R2: -CH3 177.83 3.75
23 R1: -(CH2)8CHCH2; R4: -CH2CH3 181.97 3.74
24 R1: -(CH2)8CHCH2; R2: -CH3 190.55 3.72
25 R1: -(CH2)2C6H11; R4: -CH3 194.98 3.71
26 R1: -C6H10CH3; R2: -CH3 199.53 3.70
27 R1: -(CH2)8CHCH2; R3: -CH2CH3 213.80 3.67
28 R1: -(CH2)2C6H11; R2: -CH3 218.78 3.66
29 R1: -(CH2)2C6H11; R2: -CH2CH3 269.15 3.57
30 R1: -(CH2)7CH3; R2: -CH2CH3 301.90 3.52

[a] LD50 = mM/mosquito. [b] pLD50 = −logLD50.