Table 3.

Differential expression of genes relevant to depression, in depression, after established antidepressant treatment, and following JB-1 treatment in mice. The up and down arrows represent the direction of change in pathway expression in our findings and in literature.

Gene	SGK1	GPM6B	NCDN	CLSTN1
Change in Depression	↓ in hippocampus of rats [56]	↓ in the hippocampus of humans [60]	↓ in CNS of mice [80]	↓ in blood of humans [66], ↑ in hippocampus of rats and mice [67]
Change in Depression Treatment	↑ mRNA in hippocampus and prefrontal cortex of rats following icariin or baicalin treatment [81,82]	N/A	↓ in hippocampus after ketamine treatment in rats [83]	N/A
Change Following JB-1	↑ mRNA in hippocampus of mice (4.5 × 10−2)	↑ mRNA in blood of mice (7.6 × 10−4)	↑ mRNA in blood of mice (8.5 × 10−3)	↑ mRNA in blood of mice (1.6 × 10−2)