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Genes and pathways associated with plateau animal adaptation to hypoxia, cold temperature, and high UV radiation. Hypoxia-activated pathways that regulate erythropoiesis, cardiovascular development, and oxidative phosphorylation in plateau animals are depicted in detail. Different categories of genes, i.e., CQEGs, QEGs, PSGs, and genes with L. sacra-specific mutations (LSM) are indicated by squares with different colors. Expanded CASR in L. sacra is marked with an “*”.
