Skip to main content
. 2022 Aug 25;23(17):9615. doi: 10.3390/ijms23179615

Figure 2.

Figure 2

Roles of the protein–protein interactions involving AQP0. In the developing lens fiber cell, AQP0 and Cxs join to modulate cell–cell adhesion. AQP0 interacts with ezrin to directly link the plasma membrane with the actin cytoskeleton. Lens-specific beaded intermediate filaments, BFSP1 and BFSP2, also interact with AQP0 to link the plasma membrane to cytoskeletal structures. BSFP1 fragments can reduce AQP0 water permeability. AQP0 interacts with CaM to regulate water permeability. Interactions with AKAP2 modulate AQP0 phosphorylation, which affects CaM binding and water permeability. Interactions with abundant crystallin proteins occur, but with unknown functional consequences. AKAP2: A-kinase anchoring protein 2; BFSP1: beaded filament structural protein 1 (also called filensin); BFSP2: beaded filament structural protein 2 (also called 49 kDa Cytoskeletal Protein (CP49) or phakinin); CaM: calmodulin; Cxs: connexins; PKA: protein kinase A.