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. 2022 Aug 25;23(17):9615. doi: 10.3390/ijms23179615

Figure 4.

Figure 4

Role of the protein–protein interaction involving AQP2 in kidney collecting duct cells. Upon AVP stimulation, leading to subsequent cAMP increase and PKA activation, AQP2 moves to the plasma membrane thanks to the help of various protein partners. In the absence of hormonal stimulation, AQP2 endocytosis also requires many protein partners. Due to the high number of proteins that bind to AQP2, only some of them are indicated in this figure. 14-3-3: protein 14-3-3-; AC: adenylyl cyclase; AKAP: A-kinase-anchoring protein; AVP: arginine vasopressin; cAMP: cyclic adenosine monophosphate; ERM: ezrin/radixin/moesin protein family; Gs: protein Gs; HSC70: heat shock protein 71 kDa protein; LIP5: lysosomal trafficking regulator-interacting protein 5; MAL: myelin and lymphocyte-associated protein; NEDD4: E3 ubiquitin protein ligase NEDD4; PKA: protein kinase A; PKC: protein kinase C; RhoA: small GTP-Binding Protein RhoA; SAP97: synapse-associated protein 97; Sipa1l1: signal-induced proliferation-associated 1 like 1; SPA1: signal-induced proliferation-associated gene-1; SK3: small-conductance potassium channel; TRPV4: Transient Receptor Potential Cation Channel Subfamily V Member 4: USP4: ubiquitin-specific peptidase 4.