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Schematic presentation depicting potential steps leading to liver pathogenesis from alcohol abuse. ALDH, aldehyde dehydrogenase; ADH, alcohol dehydrogenase; MEOS, microsomal ethanol-oxidizing system; CYP2E1, cytochrome P450IIE1; TNF, tumor necrosis factor; IL-1ß, interleukin-1ß; IL-8, interleukin-8; TGF-ß, transforming growth factor β1; ER, endoplasmic reticulum; LPS, lipopolysaccharide; HCC, hepatocellular carcinoma.
