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. 2022 Sep 4;23(17):10130. doi: 10.3390/ijms231710130

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Toxicity of carboxymethyllysine (CML, final 500 ng) in zebrafish embryos in the presence or absence of CIGB-258 (final 1 ng). (A) Survivability of the zebrafish embryos during 24 h post-injection. * p < 0.05; ** p < 0.01; *** p < 0.001. (B) Stereoimage of the zebrafish embryos at 24 h post-injection. Red arrowheads indicate defected development and death of embryo in CML alone group (photo c). Blue arrowhead indicates the slowest developmental speed in eye pigmentation and tail elongation in CML alone group at 26 h-post injection (photo c).

Toxicity of carboxymethyllysine (CML, final 500 ng) in zebrafish embryos in the presence or absence of CIGB-258 (final 1 ng). (A) Survivability of the zebrafish embryos during 24 h post-injection. * p < 0.05; ** p < 0.01; *** p < 0.001. (B) Stereoimage of the zebrafish embryos at 24 h post-injection. Red arrowheads indicate defected development and death of embryo in CML alone group (photo c). Blue arrowhead indicates the slowest developmental speed in eye pigmentation and tail elongation in CML alone group at 26 h-post injection (photo c).