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. 2022 Aug 31;23(17):9901. doi: 10.3390/ijms23179901

Figure 2.

Figure 2

Significantly up-regulated avian virus-specific circRNAs by functional analysis of cis-targeting genes. (A) A549 cells infected with H1N1/H7N9/H9N2 subtype IAV for 8 h. The Venn diagram reflects significantly up-regulated circRNAs (top), and the host gene-enriched pathways of circRNAs specifically up-regulated by avian origin IAV were analyzed by KEGG (bottom). (B) A549 cells infected with H1N1/H7N9/H9N2 subtype IAV for 16 h. The Venn diagram reflects significantly up-regulated circRNAs (top) and KEGG pathway analysis (bottom). Gene ratio is the ratio of the number of DE genes recorded in a pathway item to the number of all genes recorded in that pathway item. The greater the proportion of genes, the higher the intensity. p-values were adjusted ranging from 1.5 to 3.5 (blue to red). Lower p-adjustment indicates higher intensity. (C) GO analysis of specifically up-regulated host genes of circRNAs at 8 and 16 h. GO enrichment of these genes indicates that biological processes and molecular functions are most enriched, depending on the p-value.