Figure 3.

Identification of candidate YAP/TAZ/TEAD target genes in hypoxia-responsive genes in MCF7 and HCC1143 cells. (A,B) Heatmaps showing intersection of TempO-Seq data for hypoxia-regulated genes in MCF7 and HCC1143 cells with YAP/TAZ/TEAD target genes reported in literature (A; [36,37]) and candidate TEAD1-4-binding genes identified using DoRothEA (B; [38]). Values are Log₂ fold change under hypoxia relative to normoxia. Genes labeled green in (A) or labeled blue in (B) are shared between MCF7 and HCC1143 in the respective analyses. Genes labeled red in (A) and (B) are shared in both analyses for both cell lines. (C) Venn diagram showing distinct and overlapping hypoxia regulated genes for MCF7 and HCC1143 identified both in literature and by DoRothEA.