Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 4;23(17):10119. doi: 10.3390/ijms231710119

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Localization of TAZ and phosphorylated YAP/TAZ in luminal breast cancer and basal A cells under normoxia and hypoxia. (A) Localization of TAZ and p-YAP/TAZ (using an Ab detecting both p-YAP(Ser127) and p-TAZ (Ser89)) determined by confocal immune fluorescence microscopy in luminal (MCF7, T47D and BT474) and basal A (SUM149PT, HCC1806 and HCC1143) breast cancer cell lines cultured under normoxia (NX) or hypoxia (HX) for 5 days. Blue, Hoechst; Red, Abs. (B,C) Quantification of nuclear/cytoplasmic distribution of TAZ and p-YAP/TAZ in luminal (B) and basal A cells (C) cultured under normoxia or hypoxia, calculated form images in (A). Y-axis indicates percentage of the total intensity in the nuclei area versus percentage of the total intensity in the cytoplasm area. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ns, not significant.