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. 2022 Sep 5;23(17):10188. doi: 10.3390/ijms231710188

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Behaviour of rats after cerebral ischemia and L-NAME treatment according to the OFT. (A) Rat behaviour and physical appearance in each group after ischemic induction. (B) The trajectory of rats in the OFT. (C) The duration of staying in the inner and outer zone in the OFT. Data are presented as mean ± SEM (n = 6 per group). ** indicates that the difference between the Is and the CON is extremely significant (p < 0.01); # indicates that the difference between the L-NAME and the Is is significant (p < 0.05). CON: control group; Sham: sham-operated control group; Is: ischemic brain stroke group; L-NAME: pretreatment L-nitroarginine methyl ester; (L-NAME) + ischemic brain stroke group; the same below in vivo.