Table 1.
The effect of rosavin treatment on liver function and lipid profile.
| NC | NASH | RSV-10 | RSV-20 | RSV-30 | |
|---|---|---|---|---|---|
| AST (IU/L) | 21.17 ± 6.43 | 149.7 ± 36.49 * | 88.17 ± 10.68 # | 57.67 ± 5.78 #a | 36.17 ± 5.04 #a |
| ALT (IU/L) | 10.1 ± 3.62 | 179.2 ± 38.86 * | 83.05 ± 7.85 # | 45 ± 12.31 #a | 20.83 ± 6.11 #a |
| T. bilirubin (mg/dL) | 0.3967 ± 0.16 | 3.767 ± 0.47 * | 2.65 ± 0.27 # | 1.635 ± 0.14 #a | 0.715 ± 0.19 #ab |
| D. bilirubin (mg/dL) | 0.2133 ± 0.08 | 2.567 ± 0.42 * | 1.7 ± 0.33 # | 1.042 ± 0.15 #a | 0.495 ± 0.16 #ab |
| Albumin (g/dL) | 3.67 ± 0.37 | 1.68 ± 0.28 * | 2.03 ± 0.25 | 2.60 ± 0.17 #a | 3.13 ± 0.49 #a |
| AFP (ng/mL) | 19.65 ± 3.43 | 540.2 ± 108.2 * | 221.7 ± 32.16 # | 92.75 ± 20.5 #a | 29 ± 7.13 #a |
| TG (mg/dL) | 45.67 ± 4.89 | 173.7 ± 19.93 * | 104 ± 22.09 # | 73.83 ± 11.44 #a | 55.17 ± 5.19 #a |
| TC (mg/dL) | 106.6 ± 13.92 | 228.1 ± 8.81 * | 195.9 ± 7.90 # | 171.7 ± 6.93 #a | 118.2 ± 18.75 #ab |
| HDL-C (mg/dL) | 53.33 ± 3.72 | 21.67 ± 3.44 * | 33.33 ± 1.97 # | 38.17 ± 1.17 # | 45.5 ±3.51 #ab |
| LDL-C (mg/dL) | 40.17 ± 10.5 | 171.7 ± 7.61 * | 144.3 ± 8.48 # | 114.3 ± 12.14 #a | 72.17 ± 9.54 #ab |
Values are mean ± SD; number of animals = 8 rats/each group. * p < 0.001 compared to normal control group (NC). # p < 0.001 compared to NASH group, a p < 0.05 compared to Rosavin-10, b p < 0.05 compared to RSV-20. One-way ANOVA followed by Tukey’s multiple comparison test.