Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 25;23(17):9652. doi: 10.3390/ijms23179652

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Functional enrichment analysis of DEGs by Metascape (https://metascape.org/gp/index.html#/main/step1, accessed on 6 July 2022) revealed distinct pathways in SOD1- and TDP43-ALS. (A) Metascape bar chart of enriched GO and (B) Pathway terms (KEGG/Reactome/WikiPathway) across the input DEGs in SOD1-ALS. (C) Metascape bar graph of GO terms and (D) KEGG pathways that are significantly enriched in DEGs specific for TDP43-ALS datasets. X-axis represents the statistical significance of the enrichment (−log10 (p-value)). Bar chart of GO and Pathway terms colored by p-values ≤ 0.05 were adapted from Metascape, where terms containing more genes tend to have more significant p-values. The length of the bar represents the significance of that specific gene-set or term. The brighter the color, the more significant that term is.

Functional enrichment analysis of DEGs by Metascape (https://metascape.org/gp/index.html#/main/step1, accessed on 6 July 2022) revealed distinct pathways in SOD1- and TDP43-ALS. (A) Metascape bar chart of enriched GO and (B) Pathway terms (KEGG/Reactome/WikiPathway) across the input DEGs in SOD1-ALS. (C) Metascape bar graph of GO terms and (D) KEGG pathways that are significantly enriched in DEGs specific for TDP43-ALS datasets. X-axis represents the statistical significance of the enrichment (−log10 (p-value)). Bar chart of GO and Pathway terms colored by p-values ≤ 0.05 were adapted from Metascape, where terms containing more genes tend to have more significant p-values. The length of the bar represents the significance of that specific gene-set or term. The brighter the color, the more significant that term is.