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. 2022 Aug 25;23(17):9652. doi: 10.3390/ijms23179652

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Integrated analysis on hub genes further highlighted one main pathway in SOD1- and TDP43 ALS. (A) Top 10 hub genes from SOD1- and (B) TDP43-ALS identified using the cytoHubba plugin (Cytoscape) among TDP43-ALS and SOD1-ALS datasets. The deeper the color of the node, the higher the level of significance at the PPI network. (C) The hub gene-transcription factor (TF) regulatory interaction networks in SOD1- and (D) TDP43-ALS datasets. Red and pink nodes stand for the hub gene and blue and green diamond stands for the transcription factor.