Table 3.
(A) Differences between HbH and β-thalassemia [46]. (B) Differences between HbH and β-thalassemia [37].
| (A) | ||||
| Complications % | HbH, n = 72 | β-TI, n = 80 | <18 Years (n = 104) | >18 Years (n = 48) |
| Short stature | 22.2 | 42.5 | ||
| Growth retardation | 34.7 | 50 | ||
| Osteoporosis | 18 | 30 | 24 | 25 |
| Extramedullary hematopoiesis | 5.6 | 17.5 | 12.5 | 10.4 |
| Heart failure | 0 | 13.8 | 6.7 | 8.3 |
| Pulmonary hypertension | 1.4 | 5 | 2 | 3.3 |
| Gallstones | 1.4 | 2.5 | 0 | 6.3 |
| Cholecystectomy | 0 | 7.5 | 1 | 10.4 |
| Deep vein thrombosis | 0 | 2.5 | 0 | 4.1 |
| Leg ulcers | 1.4 | 3.8 | 2 | 4.1 |
| Iron overload | 11.1 | 45 | 30.8 | 25 |
| (B) | ||||
| Complications % | HbH, n = 84 | β-TI, n = 39 | Age < 10 Years, n = 94 | Age ≥ 10 Years, n = 44 |
| Spleen (splenomegaly ± splenectomy) | 55 | 51 | 49 | 66 |
| Bone (osteopenia, osteoporosis, ± bone deformity) | 17 | 36 | 12 | 41 |
| Endocrine | 32 | 26 | 21 | 52 |
| Hepatic | 25 | 15 | 16 | 36 |
| Gallbladder | 7 | 5 | 1 | 16 |
| Cardiac | 6 | 8 | 6 | 7 |
| Pulmonary hypertension | 1 | 3 | 1 | 2 |
| Infections | 25 | 15 | 21 | 18 |
| Thrombosis | 1 | 5 | 1 | 7 |