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. 2022 Sep 2;23(17):10032. doi: 10.3390/ijms231710032

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Relative mRNA expression of circadian genes differentially expressed across sex and age in SD rats (n = 6 per group). Nr1d1, Nr1d2, Arntl, Clock, Cry1, Cry2, Per1, Per2, Rora, and Rorc showed sex differences in their gene expression during liver aging. Nr1d1, nuclear receptor subfamily 1 group D member 1; Nr1d2, nuclear receptor subfamily 1 group D member 2; Arntl, aryl hydrocarbon receptor nuclear translocator like; Clock, clock circadian regulator; Cry1, cryptochrome circadian regulator 1; Cry2, cryptochrome circadian regulator 2; Per1, period circadian regulator 1; Per2, period circadian regulator 1; Rora, RAR-related orphan receptor A; Rorc, RAR-related orphan receptor C; Y, young; O, old; * p < 0.05, ** p < 0.01, and *** p < 0.001 between the two groups.