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Changes in the expression of circadian genes due to sex-different expression of Nr1d1/2. During the liver aging process, Nr1d1/2 upregulation suppressed expression of Arntl and Clock and resulted in the downregulation of other circadian genes, such as Cry1/2, Per1/2, and Rora/c. Male-specific upregulation of Nr1d1/2 might be involved in the change in circadian rhythm during male liver aging.
