Table 1.

KEGG pathways of the DEGs involved in immunity, inflammation, metabolism, and circadian rhythm from RNA-Seq data in OM vs. YM, OF vs. YF, OM vs. OF, and YM vs. YF.

Dataset	Up	Down
OM vs. YM	Natural killer cell-mediated cytotoxicity, Hematopoietic cell lineage, Rheumatoid arthritis, Cell adhesion molecules (CAMs), Fc epsilon RI signaling pathway, Antigen processing and presentation, Asthma, Jak-STAT signaling pathway, Cytokine—cytokine receptor interaction, Leukocyte transendothelial migration, Inflammatory bowel disease (IBD), B cell receptor signaling pathway, Type I diabetes mellitus, T cell receptor signaling pathway, Retinol metabolism, Primary immunodeficiency, Central carbon metabolism in cancer	Steroid hormone biosynthesis, Metabolic pathways, Retinol metabolism, Linoleic acid metabolism, Drug metabolism—other enzymes, Circadian rhythm
OF vs. YF	Maturity onset diabetes of the young, CAMs, Glycine, serine and threonine metabolism, Metabolic pathways	Drug metabolism—cytochrome P450, Nicotinate and nicotinamide metabolism, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Metabolic pathways, Pentose and glucuronate interconversions, Circadian rhythm, Steroid hormone biosynthesis, Galactose metabolism, Retinol metabolism, Fructose and mannose metabolism, Tyrosine metabolism
OM vs. OF	Natural killer cell-mediated cytotoxicity, CAMs, Rheumatoid arthritis, Leukocyte transendothelial migration, Hematopoietic cell lineage, Fc epsilon RI signaling pathway, T cell receptor signaling pathway, Primary immunodeficiency, Antigen processing and presentation, Intestinal immune network for IgA production, Asthma, Inflammatory bowel disease (IBD), B cell receptor signaling pathway	Retinol metabolism, Circadian rhythm, Ascorbate and aldarate metabolism, Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Drug metabolism—cytochrome P450, Steroid hormone biosynthesis, Drug metabolism—other enzymes, Histidine metabolism, Pentose and glucuronate interconversions, PPAR signaling pathway
YM vs. YF	Steroid hormone biosynthesis, Metabolic pathways, PPAR signaling pathway, Choline metabolism in cancer	Drug metabolism—cytochrome P450, Steroid hormone biosynthesis, Retinol metabolism, Butanoate metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Drug metabolism—other enzymes, Ascorbate and aldarate metabolism, Biosynthesis of unsaturated fatty acids, Fatty acid elongation