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. 2022 Sep 5;23(17):10199. doi: 10.3390/ijms231710199

Figure 2.

Figure 2

Tubular deletion of IKKβ alters baseline gene expression. (a) heatmaps of significantly increased mRNA of proteins important in signaling transduction and epithelial transport; (b) Heatmaps of significantly augmented mRNA expression levels coding for enzymes of metabolism (glycolysis, of lipid uptake, storage and biosynthesis) and mitochondria and mitochondrial uncoupling. IKKβ∆Tub vs. control based on genes, selected by the filter criteria DESeq p-values < 0.05; fold change > 1.5; (c,d) real-time PCR of Hk2 and Pfkfb3. Arithmetic means ± SEM of n = 4–5 per group; * p < 0.05, ** p < 0.01 using Lord test; (e) heatmaps of significantly altered genes known to ameliorate the extent of I/R injury. (#) marks the most significantly differentially altered mRNA expression level. All heatmaps show samples organized in columns and genes in rows, expression intensities are color-coded.